Antidiarrhoeal Effects of Methanolic Stem Bark Extract of Isoberlinia tomentosa (Leguminosae) in Albino Rats

1Dawa, S.I., 2Shagal, H.M., 2Nkafamiya, I.I., 3Yakubu, J., 4Sodipo, O.A., 3Mamza, U.T. and 1Adam, S

1Department of Chemistry Faculty of Science Borno State University Njimtillo PMB 1112 Maiduguri Borno State

2Department of Chemistry, Faculty of Physical Science, Modibbo Adama University Yola, P.M.B 2076, Yola, Adamawa State, Nigeria

3Department of Pure and Applied Chemistry Faculty of Science University of Maiduguri PMB 1069 Borno State Maiduguri

4Department of Clinical Pharmacology and Therapeutics, College of Medical Sciences, University of Maiduguri, Nigeria

*Corresponding author:,


The research aimed to evaluate the antidiarrhoeal effect of the methanolic stem bark extract of Isoberlinia tomentosa. The stem bark of Isoberlinia tomentosa was collected air-dried, ground to powder, and extracted with methanol using the maceration method to give a percentage yield of 8.58% w/w. The antidiarrhoeal effect of the methanol stem bark extract on castor oilinduced diarrhoea, intestinal charcoal meal transit, and castor oil-induced enteropooling was determined. The stem bark extract of Isoberlinia tomentosa exhibits significant dose-dependent protection (p0.05) between the extract doses of 100, 200, and 400 mg/kg administered. The methanol extract at 100, 200, and 400 mg/kg showed 20.4%, 68.0% and 77.0% fluid accumulation respectively. The positive control Atropine (5 mg/kg) had 81.0% inhibition of intestinal content, when compared to the negative control, which had 0% inhibition. In conclusion, the results obtained from this study revealed that the stem bark extract of Isoberlinia tomentosa possesses an antidiarrhoeal effect.


Diarrhoea, Antidiarrhoea, Isoberlinia tomentosa