Ali Abdullahi Damasak1*, Maryam Ado Mahmud1, Aliyu Daja1, Mustafa Alhaji Isa2, Mohammed Yakubu1, Bulama Burah1, Ali Abdulrahman Ali1, Muhammad Shuaibu Auwal3 and Yagana Shettima Abba1
1Department of Biochemistry, Faculty of Life Sciences, University of Maiduguri,
2Department of Microbiology, Faculty of Life Sciences, University of Maiduguri,
3Department of Veterinary Pharmacology and Toxicology, University of Maiduguri, Nigeria
*Corresponding author: aliadamasak@gmail.com, doi.org/10.55639/607.656463
ABSTRACT
Oxidative stress has been recognized as a co-occurring pathogenic process that initiates and advances liver injury. Various risk factors, such as alcohol, drugs, environmental toxins, and irradiation, can cause the liver to experience oxidative stress, which in turn can lead to serious liver conditions such as alcoholic liver disease. This study was carried out to evaluate the antioxidant potentials of methanol leaf extract of Phyllanthus niruri Linn. (Chanca piedra). The sample was obtained from Maiduguri, Borno State, Nigeria. The methanol leaves extract was subjected to qualitative phytochemical analysis and in vitro radical scavenging activity, using standard laboratory procedures. The methanol leaves extract of Phyllanthus niruri Linn. (Chanca piedra) exhibited a significant antioxidant activity on both hydrogen peroxide (H2O2) and di-phenyl-picryl hydrazyl (DPPH) radical scavenging activity assay with IC50 values of 3.70±0.06 and 6.78±0.01 μg/ml respectively, as compared to the standard (Ascorbic acid) with IC50 values of 2.39±0.01 and 1.25±0.01 μg/ml, respectively. This study therefore suggests that the methanol leaves extract of Phyllanthus niruri Linn. (Chanca piedra) possessed antioxidant activity.
Keywords:
Phyllanthus niruri Linn,
Chanca piedra,
oxidative stress,
H2O2,
DPPH