Sani Sa’idu Bello and Abudurrahman Sani Yushaú
Department of Pharmaceutical and Medicinal Chemistry, Bayero University, Kano, Nigeria
*Corresponding author’s Email: ssbello.phc@buk.edu.ng , doi.org/10.55639/607.02010025
ABSTRACT
Amoxicillin is a semi-synthetic, b-lactam antibiotic used to treat bacterial infections caused by susceptible micro-organisms. It is usually prepared in different dosage forms, which include tablet, capsule, powder for oral suspension and parenteral. The World Health Organization (WHO) has promoted using generic brands to make medicines affordable. Generic substitution could be considered when a generic copy of a reference drug contains identical amounts of the same active ingredient in the same dose formulation and route of administration. The study evaluated and compared some of the quality parameters of different generic brands of Amoxicillin capsules marketed in Kano State, Nigeria. Physical appearance test, Uniformity of weight test, Identification test and Assay of five (5) samples of Amoxicillin capsules were conducted using Standard methods (B.P. 2009) and (USP, 32). The result of the physical appearance test indicated that four (4) samples (JY01, JY02, JY03 and JY04) passed the test with an off-white appearance except for sample JY05, which failed specifications with a white colour. The same four samples passed texture specification, but JY05 failed by appearing as fine powder against crystalline powder. Likewise, identification for JY01, JY02, JY03 and JY04 showed a positive colour of dark yellow solution, while JY05 showed dark green, indicating a failed result. Similarly, the uniformity of weight of all samples, 13.52 g, 13.38 g, 13.24 g, 13.28 g and 8.41 g for JY01 – JY05, respectively, JY05 still failed this important test. Assay results of samples JY01 – JY04 passed the test with 126.4 %, 127.0 %, 128.0 %, and 129.0 %. Sample JY05 deviated from the specifications with a negative value of 0.46 %. Therefore, all the samples, except JY05, can be used interchangeably without recourse to their brand names
Keywords:
Amoxicillin,
Quality,
Uv-
Spectrophotometry,