*Moses Dele Adams
Clinical Biochemistry, Phytopharmacology and Biochemical Toxicology Research Laboratory (CBPBT-RL), Department of Biochemistry, Baze University, Abuja 900108, Nigeria.
*Corresponding author’s Email: moses.adams@bazeuniversity.edu.ng, doi.org/10.55639/607.02010068
ABSTRACT
Constipation which occurs due to build-up of ROS and inhibition of carbohydrate (CHO) hydrolyzing enzyme(s) is treated with Borassus aethiopum by locals with no report to substantiate or refute the purported activity. This study therefore seeks to assess the purgative, antioxidant and CHO enzyme hydrolyzing property of Borassus aethiopum hypocotyl ethanol extract (BAHEE) in lomotil-induced constipated rats. Thirty Wistar rats of both sexes (158.25 ± 1.35 g) were assigned into 6 groups, A-F (n=5). Group A (control) received 1 ml of saline. Constipation was induced in groups B-F by oral administration of Lomotil (3 mg/kg body weight (BW) in saline for 48 h) and treated respectively with saline, senokot (reference drug [RD] at 50 mg/kg BW), 100, 200 and 400 mg/kg BW of BAHEE for seven days using oral gavage. Lomotil induced constipation significantly (p
Keywords:
Borassus aethiopum,
Constipation,
Lomotil,
Purgative,
Oxidative stress.

