Abdullahi A. Biu1, Hauwa S. Bello2, Jummai Musa1, Maimuna A. Abdulkadir3, ThankGod E. Onyiche1
Department of Veterinary Parasitology and Entomology, University of Maiduguri, Nigeria
2 Department of Microbiology, University of Maiduguri, Nigeria
3Department of Biological Sciences, University of Maiduguri, Nigeria
*Corresponding author’s Email: email@example.com, doi.org/10.55639/607.626160
This study investigated the anthelminthic potential of aqueous extract of Guiera senegalensis leaf on earthworm (Pheretima posthuma) and Strongyline larvae cultured from sheep faeces. Graded concentrations of the extract were tested against time taken for paralysis and death of Strongyline larvae and earthworms. Anthelmintic activity of aqueous extract of Guiera senegalensis leaf based on time taken for paralysis and death of earthworm (Pheretima posthuma) indicated no significant difference (p< 0.05) between the aqueous extract and albendazole control, however time taken for both paralysis and death of the earthworm decreased in a graded dose manner. Anthelmintic activity of aqueous extract of Guiera senegalensis leaf on mortality pattern of the earthworm (Pheretima posthuma) indicated that the extract concentration of 1000mg/ml compared favourably with albendazole (6.25mg), and peak anti-Strongyline activity was noticed at extract concentrations of 250 and 500 mg/ml as well as albendazole 6.25mg. The IC50 and IC99 values for time taken for paralysis were 19.64mg/ml and 24.79mg/ml respectively while the coefficient of determination (r2) was 0.3551 and the p-value was 0.4041, and the IC50 and IC99 values for the time taken for death were 21.44mg/ml and 27.47mg/ml respectively while the coefficient of determination (r2) was 0.3420, and p-value was 0.4152. The LC50 and LC99 values for the mortality rates were 872.73 mg/ml and 411.59mg/ml and the coefficients of determination (y) were 0.33x – 238 and 0.0551x + 76.321 respectively. Findings of the present investigations confirm the ethno-medicinal claim of this plant.