Isolation and Characterization of Dammara-20,24-Dien-3-ol from Ethyl Acetate Extract of Diospyros Mespilifromis (HOCHST ex. A.DC) Root Bark

*M.D. Mustapha1 , L.G. Hassan2 , K. J. Umar2 , K. Abubakar3 , H.E. Mshelia4 , A.J. Yusuf5 T. B. Taiwo6 , S. Abubakar7 and M. Salihu8

1Department of Chemistry, Borno State University, Maiduguri, Nigeria
2Department of Pure and Environmental, Usmanu Danfodiyo University, Sokoto, Nigeria
3Department of Pharmacology, UsmanuDanfodiyo University, Sokoto, Nigeria
4Department of PharmacognosyandEthnopharmacy, UsmanuDanfodiyo University, Sokoto, Nigeria
5Department of Pharmaceutical Chemistry, UsmanuDanfodiyo University, Sokoto, Nigeria
6Department of Pharmaceutical Chemistry, OAU,Ife, Nigeria
7Department of Chemistry, Zamfara State College of Education, Maru 2, Zamfara, Nigeria
8Department of Chemistry, Shehu Shagari College of Education, Sokoto, Nigeria

*Corresponding author:,


Natural products research has been on an increase with the isolation and characterization of bioactive constituents targeted for pharmaceutical utilization and development. Diospyros mespiliformis, which belongs to the family Ebeneceae, is used locally or traditionally as an anti-bacterial, anti-fungal, and antiinflammatory agent. This work aimed at isolating bioactive constituent(s) from the root bark of Diospyros mespiliformis. The pulverized root was extracted with solvents of increasing polarity: n-hexane, ethyl acetate, ethanol, and water, with 1.41, 1.44, 8.14, and 4.33 percentage yields obtained, respectively. Dammara-20,24-dien-3-ol was isolated from the ethyl acetate extract and characterized by spectroscopic technique (13C-NMR and 1H-NMR) and by comparison with the literature data. The compound has been reported to be isolated from other plant


Diospyros mespiliformis,